- Title
- Covalent surface modification of biomimetic silica particles
- Creator
- Hyde, Emily D. E. R.; Seyfaee, Ahmad; Moreno-Atanasio, Roberto; Aubin, Joelle; Neville, Frances
- Relation
- APCChE 2015 Congress Incorporating Chemeca 2015 . Proceedings of APCChE 2015 Congress Incorporating Chemeca 2015 (Melbourne, Vic. 27 September - 1 October, 2015)
- Publisher
- Engineers Australia
- Resource Type
- conference paper
- Date
- 2015
- Description
- Micron sized silica particles are commonly used as drug carriers, biosensors and catalytic supports. Functionalisation of their surfaces allows these particles to be specifically tailored for selective interactions, which may significantly enhance their efficiency in the aforementioned practical applications. Due to the relative inertness of the silica surface, covalent surface modification commonly requires an intermediate stage through the pretreatment of the silica surface via a silane coupling agent. This agent is used to covalently link the surface and surface modifier. However, the pretreatment of the surface may result in an increase in cost and synthesis time. Biomimetic silica synthesis (Neville et al., 2009, Nanotechnology, 20:055612) can be adapted to produce silica particles with thiol surface groups. The presence of thiol surface groups is due to the use of 3-mercaptopropyltrimethoxysilane (3mPTMOS) as the silica source. Trimethoxymethylsilane (TMOMS) was also used as a silica source to produce control particles with no thiol group present on the surface of the particles. This study utilised thiol surface groups to covalently attach various surface modifiers to the particle surface while bypassing the attachment of a silane coupling agent. The modified particles were characterised via FTIR spectroscopy and zeta potential measurements to assess changes in bonding and surface charge. The results clearly demonstrated the capacity of the biomimetic silica particles to enable the attachment of other molecules to their surface.
- Subject
- silica particle synthesis; surface modifications
- Identifier
- http://hdl.handle.net/1959.13/1313335
- Identifier
- uon:22574
- Identifier
- ISBN:9781922107473
- Language
- eng
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